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lumacaftor/ivacaftor will lower the extent or impact of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of abemaciclib with potent CYP3A4 inducers minimizes plasma concentration of abemaciclib and its metabolites.It is best to browse our information regarding abemaciclib with our